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Human Chimeric Antibodies

Why choose BBI’s Human Chimeric Antibodies 

BBI Solutions’ human chimeric antibodies are reproducible and highly characterised preparations with defined purity at concentrations suitable for use as a critical raw material in rare autoimmune diseases. 

Uses of Human Chimeric Antibodies in Immunoassays 

Immunoassays for the detection of antibodies in patient samples and serological methods require reference materials to determine cut-off values and test assay integrity, and these are then included in the kit as calibrators and positive controls. One of the latest advances in assay development is the use of chimeric antibodies as an alternative to characterised disease state plasma which is limited in availability, shows variability and also has safety and ethical issues. BBI has developed a range of specific chimeric antibodies for these applications where disease state plasma is difficult to source. 

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

Disease area Product code Product Quantity
Connective Tissue Diseases

36600
36601

PCNA humAb IgG 0.1 mg
1.0 mg
37300
37301
Jo-1 humAb IgG 0.1 mg
1.0 mg
36800
36801
PL-7 humAb IgG 0.1 mg
1.0 mg
36900
36901
PL-12 humAb IgG 0.1 mg
1.0 mg
36500
36501
SRP54 humAb IgG 0.1 mg
1.0 mg
36700
36701
Mi-2 humAb IgG 0.1 mg
1.0 mg
Autoimmune Liver Diseases 36400
36401
LKM1 humAb IgG 0.1 mg
1.0 mg
37100
37101
LC1 humAb IgG 0.1 mg
1.0 mg
36200
36201
SLA/LP humAb IgG 0.1 mg
1.0 mg
37200
37201
PDC-E2 humAb IgG 0.1 mg
1.0 mg
37000
37001
Sp100 humAb IgG 0.1 mg
1.0 mg

 

How are human chimeric antibodies produced? 

Human chimeric monoclonal antibodies are produced in transgenic mouse strains in which the sequence for mouse IgG1 fc region is substituted with the human sequence. After mouse immunisation and the use of hybridoma technology, antibodies are generated that retain a human constant region for recognition by the anti-human conjugate.  

Autoantibodies against intracellular antigens are commonly found in connective tissue disorders. One example is SLE which can involve joints, kidneys, skin, mucous membranes and blood vessel walls. The idiopathic inflammatory myopathies dermatomyositis (DM) and polymyositis (PM) are characterised by the presence of inflammatory infiltrates within the skeletal muscle.  

Autoantibodies to tRNA synthetases are closely linked with AM/PM detection and diagnosis. Autoantibodies against PL-7 and PL-12 have been found in up to 6% of myositis patients. Anti SRP autoantibodies are mainly associated with a syndrome of a necrotising myopathy and severe prognosis. Autoantibodies against MI-2 are considered specific serological markers of DM. Detected in about 20% of myositis sera they are proven markers for acute onset and good response to therapy. Autoantibodies against PCNA are detected in about 5-10% of SLE patients.  

Are you developing an In Vitro assay? 

BBI now offers these specificities for IVD manufacturers developing in vitro assays that require a consistent, reliable source of raw material positive calibrator and quality control materials. Materials are stored and shipped from our Freiburg facilities. From this facility our materials are prepared and supplied directly to clients in Europe and non-China Asian territories. For customers in America and China, our Freiburg products are distributed through our carefully selected and highly reputable partners.  

 

 

Technical Documents

If you require any further product specific technical information or datasheets please submit your request to our technical team here 

Last updated: 25/06/2021

Clinical Chemistry Brochure

Last updated: 25/06/2021

Clinical Chemistry Brochure

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