What is Intrinsic Factor?
Cobalamin/vitamin B12 is essential for the formation of blood cells and DNA synthesis, and needs to be taken up with the diet. Intrinsic factor, which is secreted by the stomach, binds to vitamin B12 in the small intestine to allow its endocytosis in the ileum.
What is pernicious anaemia?
Intrinsic Factor is primarily used in the diagnosis of pernicious anaemia, a condition caused by a vitamin B12 deficiency. Prevalence in the general population varies from around 3% - 5%, and increases dramatically to 5% - 20% among people older than 65 years.
The role of Intrinsic Factor in diagnosis?
Intrinsic Factor has a high affinity and specificity to vitamin B12, which makes it ideal for use in immunoassays. Most commercial assays utilise a competitive binding technique generating a chemiluminescent signal. Commercial assays can usually detect to a level of ~50 pg/ml vitamin B12.
Why choose BBI for your Intrinsic Factor supply?
BBI is the only commercial manufacturer of high purity Intrinsic Factor. BBI’s porcine Intrinsic Factor is manufactured in the UK, under a quality system compliant with ISO 13485:2016. Using our expertise in raw material sourcing and protein purification we achieve exceptional purity, making BBI the supplier of choice for Intrinsic Factor. .