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Plasma proteins

What are plasma proteins?

Proteins that are present in blood plasma and have many different functionalities, such as the transport of various biochemical (lipids, hormones etc.) in the circulatory system to the regulation of the osmotic pressure, helping maintain the balance of fluid and electrolyte levels in the body.

Many different proteins are found in blood plasma, but some are found in trace amounts of less than 1% of the total plasma. Some of the more common plasma proteins found in blood plasma are as follows:

Serum Albumin

Is the most abundant protein found in blood plasma. It has many different functions within the body such as, the nourishment of cells, the transportation of biomolecules around the body. E.g. hormones, fatty acids. It’s most important function is the regulation of the osmotic pressure, this is essential for maintaining the fluid and electrolyte balance in the body.

Monitoring of serum albumin is a useful diagnostic tool to indicate if the kidney or liver has been damaged, as levels of albumin drop when damaged has occurred.

Fibrinogen

Is a large glycoprotein that helps in the formation of blood clots. It is released into the circulation when a body tissue or blood vessel wall is injured and is one of over 20 other clotting factors that aid the “coagulation cascade” The fibrinogen is converted to fibrin by thrombin during the blood clotting process. Elevated levels of fibronectin in the blood are a useful prognostic for stroke.

Globulins

Make up a smaller proportion of the blood plasma, but are important in providing antibodies. Globulins are actually sub divided in to 3 categories and has different functionalities:

  • Alpha Globulin and Beta Globulin – Transporters for fat soluble vitamins, hormones and lipids.
  • Gamma Globulin – Gamma globulins are also classified as “immunoglobulins” and provide protection against disease at a cellular level and are synthesised in the lymphoid tissue.

Are you developing an assay to detect levels of plasma proteins?

BBI can help.

We offer a diverse range of markers that are ideal for numerous applications including life science research, immunodiagnostic platform assays, ELISA’s, lateral flow, and quality assurance control manufacture.

See the table below for details on our flagship products in the plasma proteins area.

Name

Function

Human Albumin Human Albumin is a protein that binds many blood components from metal ions, fatty acids and bilirubin to drugs and hormones, to enable their transport. It has a mol wt of 66kDa and pI 4.7.
Retinol Binding Protein Retinol Binding Protein (RBP) is a protein of 21 kDa and pI of 4.7. In conjunction with Prealbumin it is useful for assessing nutritional status. RBP is readily filtered by the glomerulus and absorbed by the proximal renal tubules, as such it is valuable for the assessment of renal tubular function.
Tamm Horsfall Glycoprotein Tamm Horsfall Glycoprotein is a 80 kDa protein with 20% carbohydrate content. It is urine specific and can be used to confirm the nature of a suspect urine sample when urea and creatinine measurements are ambiguous.

Find out more about our range of plasma proteins, visit the BBI store >>

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