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Autoimmune markers

The World Health Organization (WHO) estimates that 1 in 5 individuals suffer from some form of autoimmune disease.

Autoimmune disorders are diseases that can occur when the host recognises one of its own constituents as a foreign body and creates antibodies that target this entity for attack from the immune system. This can often lead to a chronic inflammatory response.

Autoimmune disorders fall into two general types:

  • Those that damage many organs (systemic autoimmune diseases)
  • Those where only a single organ or tissue is directly damaged by the autoimmune process (localised)

The range of autoimmune disease is broad, ranging from such systemic illnesses like Systemic Lupus, to highly specific disease such as those of the thyroid gland such as Hashimoto’s Disease.

There are more than 80 recognised autoimmune diseases or autoimmune-related disorders, with another 40 diseases considered possible autoimmune diseases. The top six (based on the number of patients treated for the diseases) are:

1. Rheumatoid arthritis (RA)

2. Type 1 diabetes

3. Systemic lupus erythematosus (SLE)

4. Multiple sclerosis (MS)

5. Inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis)

6. Psoriasis

Autoimmune disease is usually treated by the use of steroids, immune suppressors or plasma exchange, and treatment is often monitored using diagnostic tests.

The tests require reasonably large amounts of consistently made protein as, in the case of these tests, the protein is acting as the capture molecule in the way an antibody acts in a “normal” diagnostic assay.

Are you developing an assay to detect an autoimmune disorder?

BBI can help.

We offer a diverse range of markers that are ideal for numerous applications including life science research, immunodiagnostic platform assays, ELISA’s, lateral flow, and quality assurance control manufacture.

See the table below for details on our flagship products in the autoimmune disease area.

 

Name

Function

Alpha-1 Antitrypsin Alpha-1-antitrypsin (A1AT) is a glycoprotein with a molecular weight of 54 kDa and pI of 4.8. It is a serine protease inhibitor which acts to limit the amount of cell damage and death at the tissue site. Different isoenzymes exist which together form the protease inhibitor system. Phenotype M is the most common and certain variants (S and Z) are associated with alpha-1-antitrypsin deficiency which can lead to emphysema and liver disease.
Histones Histone antigen, purified from HeLa cells is closely associated with genomic DNA. They show significant IgG autoimmune response with approx. 50% of Systemic lupus erythematosus (SLE) patients and about 95% of drug induced SLE patients.
Proteinase 3 Proteinase 3 is the antigen for autoantibodies which display a C-ANCA pattern seen in 90% of cases of patients with Wegener’s arteritis. The level of antibody can be used to monitor immunosuppressive treatment.

 

Find out more about our range of autoimmune proteins, visit the BBI store >>

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