Galectin-3 belongs to the lectin family and is a carbohydrate binding protein. It is predominantly expressed in the colonic and intestinal epithelium. It is also found in the activated macrophages, fibroblasts, tumor cells. The marker is associated with cancer, inflammation and fibrosis, heart disease and stroke. There are various research papers which have suggested different uses of Galectin-3 as a diagnostic marker; a pre-surgical marker for thyroid carcinoma, cell proliferation stimulant, differentiation of benign and malignant thyroid neoplasms, analysis of colorectal cancer progression and Crohns disease. It also has the ability to chemo attract human blood monocytes and macrophages.
|Applications||Academic, Biosensors, Clinical Chemistry, Control Manufacture, ELISA, Lateral Flow, Life Science|
|Disease Area||Cardiac Markers|
|Keywords||Recombinant Human Galectin-3, Gal-3, Mac-2 antigen, Galactose-specific lectin 3|
|Molecular Weight||26000 Da|
|NCBI Entrez Gene ID||3958|
|Presentation Matrix||Single homogenous batch, supplied lyophilised from 0.02M NH4HCO3. May contain traces of buffer salts|
|Product Category||This is an R&D Prototype recombinant antigen|
|Purity/Grade||>96%, defined by Coomassie stained SDS-PAGE|
Galectin -3 is an emerging prognostic biomarker in Heart Failure. Elevated levels are also associated with a variety of cancer types. The recombinant protein can be used as a reagent for creating immunoassay standards and controls.
|Shipping Recommendation||Below -15°C|
|Solubility||IIt is recommended that PBS is used to reconstitute the material|
|Source||Recombinant from Escherichia Coli|
|Storage||Store -15°C or below|