Developing an easy to use, sensitive over the counter (OTC) diagnostic for STIs, supported with an app-based reader with guided instructions to allow for easier self-testing, could herald a new approach to targeting sexually transmitted infections.
Secondary antibodies are a common and critical component of immunoassays. Simply stated, a secondary antibody is a reagent which recognizes an antibody of another species used to detect an analyte. A multitude of secondary antibodies are used throughout research and diagnostic applications. Secondary antibodies can be: monoclonal or polyclonal, from numerous species, directed towards any portion of the target immunoglobulin and typically direct conjugated to a reporter molecule.
Dr Stephen Pelsue, Science Director, at BBI’s custom antibody services facility discusses the fundamentals of affinity maturation and the impact on improving antibody binding for immunoassays.
In wake of the 2018 World Cup, global gatherings on such an unprecedented scale have the potential for an infectious disease outbreak. Areas where lots of people congregate offer the perfect breeding ground for norovirus.
Huge strides have been made to tackle the human immunodeficiency virus (HIV) but with recent statistics highlighting that many communities where HIV is still rife. Continued progress is needed and developing innovative diagnostics to create an effective first line of defence against HIV, is crucial.
Point of care diagnostic to distinguish between inflammatory bowel disease and irritable bowel syndrome
Inflammatory Bowel Disease (IBD) is often described as an ‘invisible’ illness. It has no known cure, affects over 300,000 people in the UK and is becoming more common especially among young people.
With mHealth apps forecast to generate $189 billion annual revenue to app providers by 2020, pharma companies hoping to jump on the mHealth bandwagon may soon find themselves facing an interesting question — how do I make money from the app?
An antigen is any structure that can be recognized by an antibody, however the binding of the antigen to an antigen receptor (membrane bound antibody) does not necessarily lead to the lymphocyte activation and the development of an immune response. A substance that has the ability to drive an immune response is referred to as an immunogen. An immunogen is also an antigen, but not all antigens are immunogens.
Rheumatoid arthritis (RA) is a chronic inflammatory disease which can lead to the risk of premature death. Traditional guidelines for diagnosing RA were developed in 1987 were dependent on a combination of clinical, laboratory and radiographic features. An update to these guidelines gives assay developers the opportunity to bring test into the point of care setting providing the opportunity for earlier detection and better patient outcomes.
The immune system has the capacity to develop antibodies that can specifically bind to almost any biological or chemical structure imaginable. This remarkable repertoire of antibody specificity is defined by the variable region domains of the heavy (VH) and light (VL) chains of the heterodimeric antigenic determinant region, which generates an estimated 1-6 X 106 combinations in mice and humans through the rearrangement of VH and VL genes.