Stabilisers Header.jpg

Stabilisers

Stabilisers to improve assay performance

BBI offers a range of protein and non-protein based reagents designed to improve the performance of IVD assays. BBI supplies the Surmodics branded range of stabilisers to it EU based clients. StabilCoat™, StabilBlock™ and StabilGuard™ product ranges effectively preserve the conformation and activity of proteins while simultaneously blocking the surface to reduce non‐specific binding. The products can be used to stabilise antibodies, antigens or enzymes on an assortment of immunoassay components: polystyrene plates, tubes, glass, membranes, and filter paper.  

The non‐specific binding of serum proteins, conjugates and other assay components to solid surfaces in immunoassay applications requires that a blocking step be incorporated into the protocol to maximize assay sensitivity.  Additionally, the manufacturing of immunoassay test kits requires long-term protein stability to increase the manufacturing scale and extend shelf lives for the end user.  The different formulations allow these requirements to be accomplished in a single step while easily being substituted for the blocking solution in an existing assay protocol. 

StabilZyme™ conjugate/protein stabilisers protect the entire conjugate by preventing the loss of catalytic activity and maintaining the structural integrity of the protein in solution. These stabilisers allow for the storage of conjugated proteins at lower use concentrations, extended shelf life and increased signal‐to‐noise ratios for improved assay performance. Materials are provided as ready to use formulations or concentrates in specific buffered matrix designed for optimal performance.  

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

 

 

 

 

 

 

 

 

 

Related Products

If you require any further product specific technical information or datasheets please submit your request to our technical team here 

Stabiliser properties

BBI offers the Surmodics brand range of IVD assay stabilisers.  Surmodics’ immunoassay stabilisation products preserve the conformation of proteins in their native folded state when dried or lyophilized and then coated to a range of surfaces, including microtiter plates, latex beads and magnetic particles. This stability gives you confidence in the viability of the antigens and/or antibodies you incorporate as key components of your diagnostic tests.  

The non‐specific binding of serum proteins, conjugates and other assay components to solid surfaces in immunoassay applications requires that a blocking step be incorporated into the protocol to maximise assay sensitivity.  Additionally, the manufacturing of immunoassay test kits requires long-term protein stability to increase the manufacturing scale and extend shelf lives for the end user.  The StabilCoat™, StabilGuard™ and StabilBlock™ formulations are adapted to specific applications and allow for these requirements to be accomplished in a single step while easily being substituted for the blocking solution in an existing assay protocol. These materials have been designed in buffered solutions that prevent non-specific molecules binding to active surfaces, decreasing background signal and enhancing long-term stability of biological products. The specific product most suited to the application can be determined by experiment.  

Generating protein arrays requires assurance that the biologically active structure of proteins remains intact and stable in the presence of external factors, such as temperature, pH, metal ions, and other contaminants. Surmodics’ stabilisation products for protein microarrays preserve the conformation of proteins in their native, folded state when coated to surfaces such as microarray slides or beads used in multiplexing protein assays. The StabilZyme™ range of conjugate stabilisers is optimised to maintain the conformation of antibodies/antigens conjugated to signal enzymes such as BBI’s Alkaline Phosphatase in solution.  Adding the conjugate directly into the  solution allows for stable storage of the conjugate at a working concentration and eliminates the need for subsequent dilutions.    

Technical Documents

If you require any further product specific technical information or datasheets please submit your request to our technical team here 

Request a callback

BBI Solutions Brands

diarect.png

The acquisition of DIARECT in June 2020 and their world leading recombinant autoimmune antigen capability immediately enhances BBI’s portfolio and position as a ‘complete’ immunoassay reagent supplier. This further enhances BBI’s position as the world’s largest diagnostics components company with a market leading antigen portfolio.

mbs.png

Maine Biotechnology Services brings 27 years of knowledge, experience, process development, and project management to our customers to ensure the best possible antibodies for any application. As antibody development goals in the biotechnology and pharmaceutical industry have evolved the acquisition of MBS will help BBI further meet and exceed our customers needs.

Newsletter

Signup for our newsletter to receive the latest BBI Solutions updates and special offers in your inbox