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Signal Enhancers

Signal Enhancers - Streptavidin and Polystreptavidin

Streptavidin is a tetrameric protein (4 x 13 kDa), which binds very tightly to the small molecule Biotin. The binding of streptavidin to biotin is one of the strongest known non-covalent biological bonds, and is resistant to breaking by temperature, pH, solvents and other chemical influences. Biotin will displace almost any other molecule bound to streptavidin and can be easily conjugated to other biomolecules which makes this a highly effective binding system for use in a wide range of applications, particularly immunoassay. A single molecule of streptavidin can bind up to 4 biotin/biotinylated proteins. However, the use of Polystreptavidin allows for many more biotin molecules to bind to a single molecule. The use of Polystreptavidin can reduce noise, increase signal and specificity, and significantly reduce the cost of reagents in the development of immunoassays. 

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

Related Products

If you require any further product specific technical information or datasheets please submit your request to our technical team here 

Polystreptavidin from BBI

A chemically modified polymer made from recombinant streptavidin plus native avidin with an exceptional capacity for biotin binding.   

Our formulation is a solution of Polystreptavidin in 0.05M Phosphate Buffered Saline containing 0.05% NaN3, pH 7.4 at a concentration between 1-5 mg/ml ready for coating. 

Our Polystreptavidin reagents have the potential to improve not only the sensitivity of lateral flow tests but also the signal-to-noise ratio, all whilst saving material costs.   


  • High biotin binding capacity in low concentrations  
  • High affinity and high signal-to-noise ratio  
  • No washing or blocking steps required  
  • High homogeneity and generous shelf life  
  • High thermo and chemical stability 



























Technical Documents

If you require any further product specific technical information or datasheets please submit your request to our technical team here 

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BBI Solutions Brands


The acquisition of DIARECT in June 2020 and their world leading recombinant autoimmune antigen capability immediately enhances BBI’s portfolio and position as a ‘complete’ immunoassay reagent supplier. This further enhances BBI’s position as the world’s largest diagnostics components company with a market leading antigen portfolio.


Maine Biotechnology Services brings 27 years of knowledge, experience, process development, and project management to our customers to ensure the best possible antibodies for any application. As antibody development goals in the biotechnology and pharmaceutical industry have evolved the acquisition of MBS will help BBI further meet and exceed our customers needs.


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