Infectious Disease & Biothreat

BBI’s Infectious Disease Antigens

The focus for our range of infectious disease antigens has been to derive targets for specific disease states where a high quality and high specification reproducible product is required to give the best performance across different assay platforms.

The antigens offered have been designed after careful consideration of the target organism proteome and the proteins have been selected based on rigorous testing.

BBI derives its range of infectious disease antigens by molecular methods and the proteins are expressed in specific host organisms. The host cell lines are stored and propagated in our specific bioreactor systems. Some of our recombinant products are expressed with specific His-tag sequences to facilitate purification by nickel chelate affinity chromatography. Other materials are purified by a series of different chromatography techniques. The purified proteins are then formulated liquid or lyophilised in the most appropriate stabilising buffer and filtered to 0.2µm to ensure low bioburden.

Products are characterised prior to fill to determine the recovery and purity of the protein using a range of analytical techniques. Techniques such as Coomassie stained SDS-PAGE are used to test and verify the product purity. After the products have been filled and formulated, they are retested by our independent Quality Control laboratory to verify the analytical results and define the biological integrity.

Products

Product Name	Code	Type	Applications
HIV p24 antigen (recombinant)	P714-3	Antigens/Proteins	Biosensor, Clinical Chemistry, Control Manufacture, ELISA, Life Sciences	Buy now

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Products & Services

Inside this catalog you’ll find one of the industry’s broadest collections of enzymes, antibodies, antigens, and more – meticulously developed to power world-class diagnostics and keep your pipeline moving.

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Reagents Range

Discover our collection of reagents covering a comprehensive range of biomarkers and applications for the IVD market, life sciences, cell culture and beyond.

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Antibody Development

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What are antigens and how are they used?

BBI antigens are purified human proteins—either native or recombinant—that serve as critical reagents for making in-vitro-diagnostic (IVD) calibrators and quality-control materials; in some cases they also provide specific biological functionality for research or cell-based assays.

What is the source material for your antigens?

Depending on the product, antigens are produced recombinantly in prokaryotic or eukaryotic systems, purified from consented human tissues or body fluids, or harvested from well-characterised human cell lines.

Where are the antigens manufactured and purified?

Manufacturing takes place at BBI’s ISO 13485-certified facilities in Crumlin, UK, and Freiburg, Germany, both of which operate strict quality-management systems and traceable batch records.

How does BBI guarantee lot-to-lot consistency?

Every production lot follows documented SOPs, is subjected to biochemical and immunological testing, and must meet tight release specifications before it leaves QC, ensuring reproducible performance in your assay.

How should I handle the material when it arrives?

Store at the temperature specified on the CoA.

How can I obtain pricing?

Pricing is volume-dependent; you can check our online shop or request a formal quotation from your account manager or contact customer services.

How do I check stock availability or secure future supply?

Your account manager can provide current inventory levels, arrange reservations, and help integrate your six-month forecasts into our production planning. You can also contact us or use our online shop if you don’t have an account manager yet.

What is the process if I have a complaint or quality concern?

All complaints should be sent to Complaints@bbisolutions.com. All issues are investigated under BBI’s ISO 13485 quality-management system, and we will work with you to reach a satisfactory resolution.

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Why Infectious Disease Antigens from BBI?

For our infectious disease antigens, we offer a selected range targeting specific viral and bacterial proteins derived using molecular methods and using carefully chosen recombinant expression systems. Products are made to order or available from stock using processes defined by specific batch records. We endeavour to always supply material to our customers’ timelines but rely on our clients to provide forecasts and estimates of usage.

Materials are prepared using a range of purification technologies, some of these unique to BBI.  Products are available highly purified and are formulated to optimise shelf-life. We provide material in the most convenient storage format, often stored in ultra-cold systems to ensure maximum shelf-life.

Analytical testing is performed to demonstrate the product purity and recovery using immunological and/or biochemical protein assays.  Products are often tested with or referenced against specific stored patient samples to ensure the performance.

Global Supply

Materials are stored and shipped from our Crumlin or Freiburg facilities. Materials produced at our Crumlin facility are shipped directly to all our customers in all territories worldwide. Antigens prepared at our Freiburg facility are supplied directly to clients in Europe and non-China Asia territories.  For customers in America and China our Freiburg antigens are distributed through our carefully selected and highly reputable partners.

BBI has a range of specific infectious disease antigen products which are supplied as standard products from stock, plus there are several products that we make to order. As we are the manufacturer, we can provide the most cost-effective solution for our clients.

Core Competencies

Large product range

Quality

Stability

Custom manufacture

Our product range includes enzymes for biosensor, immunoassay, clinical chemistry, molecular and pharmaceutical applications with a range of different grades to suit all applications.

We aim to develop, manufacture and supply high quality enzymes which meet both customer and regulatory requirements.

We use quality raw materials, innovative production methods and product formulations to achieve maximum stability for our products. We test our products regularly to ensure this remains consistent.

If one of our off-the-shelf products does not meet your requirements, we can offer custom development and manufacturing services to deliver an enzyme to your specification, perfect for your application.